General description

An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P₄) antagonist (IC₅₀ = 25 nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC₅₀ = 6.4 µM, 3.9 µM, 5.5 µM, and 25 µM for S1P₁, S1P₂, S1P₅, and S1P₃ (95% inhibition), respectively).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Guerrero, M., et al. 2011. Bioorg. Med. Chem. Lett.21, 3632.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Regulatory Review (Z)